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Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

The TIM22 protein import pathway mediates the import of membrane proteins into the mitochondrial inner membrane and consists of two intermembrane space chaperone complexes, the Tim9-Tim10 and Tim8-Tim13 complexes. To facilitate mechanistic studies, we developed a chemical-genetic approach to identif...

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Auteurs principaux: Hasson, Samuel A., Damoiseaux, Robert, Glavin, Jenny D., Dabir, Deepa V., Walker, Scott S., Koehler, Carla M.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2010
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906835/
https://ncbi.nlm.nih.gov/pubmed/20457929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914387107
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