Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

The TIM22 protein import pathway mediates the import of membrane proteins into the mitochondrial inner membrane and consists of two intermembrane space chaperone complexes, the Tim9-Tim10 and Tim8-Tim13 complexes. To facilitate mechanistic studies, we developed a chemical-genetic approach to identif...

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Hlavní autoři: Hasson, Samuel A., Damoiseaux, Robert, Glavin, Jenny D., Dabir, Deepa V., Walker, Scott S., Koehler, Carla M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906835/
https://ncbi.nlm.nih.gov/pubmed/20457929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914387107
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