Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation

The TIM22 protein import pathway mediates the import of membrane proteins into the mitochondrial inner membrane and consists of two intermembrane space chaperone complexes, the Tim9-Tim10 and Tim8-Tim13 complexes. To facilitate mechanistic studies, we developed a chemical-genetic approach to identif...

Full description

Saved in:
Bibliographic Details
Main Authors: Hasson, Samuel A., Damoiseaux, Robert, Glavin, Jenny D., Dabir, Deepa V., Walker, Scott S., Koehler, Carla M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906835/
https://ncbi.nlm.nih.gov/pubmed/20457929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914387107
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items