Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44

Diverse protein import pathways into mitochondria use translocons on the outer membrane (TOM) and inner membrane (TIM). We adapted a genetic screen, based on Ura3 mistargeting from mitochondria to the cytosol, to identify small molecules that attenuated protein import. Small molecule mitochondrial i...

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Vydáno v:J Biol Chem
Hlavní autoři: Miyata, Non, Tang, Zhiye, Conti, Michael A., Johnson, Meghan E., Douglas, Colin J., Hasson, Samuel A., Damoiseaux, Robert, Chang, Chia-en A., Koehler, Carla M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392686/
https://ncbi.nlm.nih.gov/pubmed/28167535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770131
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