RUNX REGULATION OF SPHINGOLIPID METABOLISM AND SURVIVAL SIGNALLING

The Runx genes (Runx1, 2 and 3) regulate cell fate in development and can operate as either oncogenes or tumour suppressors in cancer. The oncogenic potential of ectopic Runx expression has been demonstrated in transgenic mice that develop lymphoma in potent synergy with over-expressed Myc, and in e...

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Bibliografiske detaljer
Main Authors: Kilbey, A., Terry, A., Jenkins, A., Borland, G., Zhang, Q., Wakelam, M.J.O., Cameron, E.R., Neil, J.C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906707/
https://ncbi.nlm.nih.gov/pubmed/20587518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0726
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