Silk-elastinlike protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck tumors

BACKGROUND: Adenoviral directed enzyme prodrug therapy is a promising approach for head and neck cancer gene therapy. Challenges with this approach however are transient gene expression and dissemination of viruses to distant organs. METHODS: We used recombinant silk-elastinlike protein copolymer (S...

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Main Authors: Greish, Khaled, Frandsen, Jordan, Scharff, Stephanie, Gustafson, Joshua, Cappello, Joseph, Li, Daqing, O’Malley, Bert W., Ghandehari, Hamidreza
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906606/
https://ncbi.nlm.nih.gov/pubmed/20603862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1469
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