Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1

BACKGROUND: Activin receptor-like kinase 1 (ALK1) is a Transforming Growth Factor-β (TGF-β) receptor type I, mainly expressed in endothelial cells that plays a pivotal role in vascular remodelling and angiogenesis. Mutations in the ALK1 gene (ACVRL1) give rise to Hereditary Haemorrhagic Telangiectas...

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Main Authors: Garrido-Martin, Eva M, Blanco, Francisco J, Fernandez-L, Africa, Langa, Carmen, Vary, Calvin P, Lee, Ursula E, Friedman, Scott L, Botella, Luisa M, Bernabeu, Carmelo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906440/
https://ncbi.nlm.nih.gov/pubmed/20587022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-11-51
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