Complement Regulator Factor H Mediates a Two-step Uptake of Streptococcus pneumoniae by Human Cells

Streptococcus pneumoniae, a human pathogen, recruits complement regulator factor H to its bacterial cell surface. The bacterial PspC protein binds Factor H via short consensus repeats (SCR) 8–11 and SCR19–20. In this study, we define how bacterially bound Factor H promotes pneumococcal adherence to...

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Hlavní autoři: Agarwal, Vaibhav, Asmat, Tauseef M., Luo, Shanshan, Jensch, Inga, Zipfel, Peter F., Hammerschmidt, Sven
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Microbiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906339/
https://ncbi.nlm.nih.gov/pubmed/20504767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.142703
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