Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen

Arterial thrombosis, a major cause of myocardial infarction and stroke, is initiated by activation of blood platelets by subendothelial collagen. The protein kinase C (PKC) family centrally regulates platelet activation, and it is becoming clear that the individual PKC isoforms play distinct roles,...

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Detalhes bibliográficos
Main Authors: Gilio, Karen, Harper, Matthew T., Cosemans, Judith M. E. M., Konopatskaya, Olga, Munnix, Imke C. A., Prinzen, Lenneke, Leitges, Michael, Liu, Qinghang, Molkentin, Jeffery D., Heemskerk, Johan W. M., Poole, Alastair W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906332/
https://ncbi.nlm.nih.gov/pubmed/20479008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.136176
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