Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

Platelets are activated by adhesion to vascular collagen via the immunoglobulin receptor, glycoprotein VI (GPVI). This causes potent signaling toward activation of phospholipase Cγ2, which bears similarity to the signaling pathway evoked by T- and B-cell receptors. Phosphoinositide 3-kinase (PI3K) p...

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Detalhes bibliográficos
Main Authors: Gilio, Karen, Munnix, Imke C. A., Mangin, Pierre, Cosemans, Judith M. E. M., Feijge, Marion A. H., van der Meijden, Paola E. J., Olieslagers, Servé, Chrzanowska-Wodnicka, Magdalena B., Lillian, Rivka, Schoenwaelder, Simone, Koyasu, Shigeo, Sage, Stewart O., Jackson, Shaun P., Heemskerk, Johan W. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797144/
https://ncbi.nlm.nih.gov/pubmed/19815551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048439
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