Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

Platelets are activated by adhesion to vascular collagen via the immunoglobulin receptor, glycoprotein VI (GPVI). This causes potent signaling toward activation of phospholipase Cγ2, which bears similarity to the signaling pathway evoked by T- and B-cell receptors. Phosphoinositide 3-kinase (PI3K) p...

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Autores principales: Gilio, Karen, Munnix, Imke C. A., Mangin, Pierre, Cosemans, Judith M. E. M., Feijge, Marion A. H., van der Meijden, Paola E. J., Olieslagers, Servé, Chrzanowska-Wodnicka, Magdalena B., Lillian, Rivka, Schoenwaelder, Simone, Koyasu, Shigeo, Sage, Stewart O., Jackson, Shaun P., Heemskerk, Johan W. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797144/
https://ncbi.nlm.nih.gov/pubmed/19815551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048439
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