Identification of Novel Specific Allosteric Modulators of the Glycine Receptor Using Phage Display

The glycine receptor (GlyR) is a member of the Cys-loop superfamily of ligand-gated ion channels and the major mediator of inhibitory neurotransmission in the spinal cord and brainstem. Many allosteric modulators affect the functioning of members of this superfamily, with some such as benzodiazepine...

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Bibliografiske detaljer
Main Authors: Tipps, Megan E., Lawshe, Jessica E., Ellington, Andrew D., Mihic, S. John
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906275/
https://ncbi.nlm.nih.gov/pubmed/20501662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.130815
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