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Elastase-mediated Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein at Discrete Sites within the S2 Domain

Proteolytic priming is a common method of controlling the activation of membrane fusion mediated by viral glycoproteins. The severe acute respiratory syndrome coronavirus spike protein (SARS-CoV S) can be primed by a variety of host cell proteases, with proteolytic cleavage occurring both as the S1/...

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Autori principali: Belouzard, Sandrine, Madu, Ikenna, Whittaker, Gary R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906266/
https://ncbi.nlm.nih.gov/pubmed/20507992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.103275
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