Reprogramming towards pluripotency requires AID-dependent DNA demethylation

Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes possible derivation of patient-specific stem cells for regenerative medicine. However, iPS cell generation is asynchronous and slow (2–3 weeks), the frequency is low (, 0.1%), and DNA demethylation constitutes a...

Full description

Saved in:
Bibliographic Details
Main Authors: Bhutani, Nidhi, Brady, Jennifer J., Damian, Mara, Sacco, Alessandra, Corbel, Stéphane Y., Blau, Helen M.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906123/
https://ncbi.nlm.nih.gov/pubmed/20027182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08752
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items