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Reprogramming towards pluripotency requires AID-dependent DNA demethylation
Reprogramming of somatic cell nuclei to yield induced pluripotent stem (iPS) cells makes possible derivation of patient-specific stem cells for regenerative medicine. However, iPS cell generation is asynchronous and slow (2–3 weeks), the frequency is low (, 0.1%), and DNA demethylation constitutes a...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906123/ https://ncbi.nlm.nih.gov/pubmed/20027182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08752 |
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