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Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline [Image: see text]

BACKGROUND: Previous cross-sectional fMRI studies in subjects with prodromal Alzheimer disease (AD) have reported variable results, ranging from hypoactivation, similar to patients with AD, to paradoxically increased activation or hyperactivation compared to cognitively normal older individuals. We...

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書誌詳細
主要な著者: O'Brien, J.L., O'Keefe, K.M., LaViolette, P.S., DeLuca, A.N., Blacker, D., Dickerson, B.C., Sperling, R.A.
フォーマット: Artigo
言語:Inglês
出版事項: American Academy of Neurology 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905893/
https://ncbi.nlm.nih.gov/pubmed/20463288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3181e3966e
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