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Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline [Image: see text]

BACKGROUND: Previous cross-sectional fMRI studies in subjects with prodromal Alzheimer disease (AD) have reported variable results, ranging from hypoactivation, similar to patients with AD, to paradoxically increased activation or hyperactivation compared to cognitively normal older individuals. We...

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Detalhes bibliográficos
Main Authors: O'Brien, J.L., O'Keefe, K.M., LaViolette, P.S., DeLuca, A.N., Blacker, D., Dickerson, B.C., Sperling, R.A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Academy of Neurology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905893/
https://ncbi.nlm.nih.gov/pubmed/20463288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e3181e3966e
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