Zinc Binding Properties of Engineered RING Finger Domain of Arkadia E3 Ubiquitin Ligase

Human Arkadia is a nuclear protein consisted of 989 amino acid residues, with a characteristic RING domain in its C-terminus. The RING domain harbours the E3 ubiquitin ligase activity needed by Arkadia to ubiquitinate its substrates such as negative regulators of TGF-β signaling. The RING finger dom...

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Bibliografiske detaljer
Main Authors: Chasapis, Christos T., Loutsidou, Ariadni K., Orkoula, Malvina G., Spyroulias, Georgios A.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905715/
https://ncbi.nlm.nih.gov/pubmed/20689703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/323152
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