Synthesis and Biological Evaluation of New CRH Analogues

A series of 7 new human/rat Corticotropin Releasing Hormone (h/r-CRH) analogues were synthesized. The induced alterations include substitution of Phe at position 12 with D-Phe, Leu at positions 14 and 15 with Aib and Met at positions 21 and 38 with Cys(Et) and Cys(Pr). The analogues were tested rega...

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Bibliographic Details
Main Authors: Papazacharias, Spyridon, Magafa, Vassiliki, Bernad, Nicole, Pairas, George, Spyroulias, Georgios A., Martinez, Jean, Cordopatis, Paul
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905701/
https://ncbi.nlm.nih.gov/pubmed/20689735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/252348
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