Synthesis and Biological Evaluation of Carbocyclic Analogues of Pachastrissamine

A series of carbocyclic analogues of naturally-occurring marine sphingolipid pachastrissamine were prepared and biologically evaluated. The analogues were efficiently synthesized via a tandem enyne/diene-ene metathesis reaction as a key step. We found that the analogue 4b exhibited comparable cytoto...

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Detalhes bibliográficos
Main Authors: Yongseok Kwon, Jayoung Song, Hoon Bae, Woo-Jung Kim, Joo-Youn Lee, Geun-Hee Han, Sang Kook Lee, Sanghee Kim
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2015-02-01
Colecção:Marine Drugs
Assuntos:
pachastrissamine
jaspine B
carbocyclic analogue
cytotoxicity
sphingosine kinase inhibitor
molecular modeling
Acesso em linha:http://www.mdpi.com/1660-3397/13/2/824
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