BIOENGINEERED ARGINASE I INCREASES CASPASE-3 EXPRESSION OF HEPATOCELULAR AND PANCREATIC CARCINOMA CELLS DESPITE INDUCTION OF ARGININOSUCCINATE SYNTHETASE-1

BACKGROUND: Hepatocellular and pancreatic carcinomas are often auxotrophic for L-arginine, a semi-essential amino acid. The purpose of this study was to investigate cancer cell death using a significantly more active, cobalt-substituted bioengineered arginase. METHODS: Panc-1, a human pancreatic car...

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Detalhes bibliográficos
Main Authors: Glazer, E. S., Kaluarachchi, W. D., Massey, K. L., Zhu, Cihui, Curley, S. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905509/
https://ncbi.nlm.nih.gov/pubmed/20466402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2010.03.022
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