Combining the FLT3 Inhibitor PKC412 and the Triterpenoid CDDO-Me Synergistically Induces Apoptosis in Acute Myeloid Leukemia with ITD mutation

Mutations of the FLT3 receptor tyrosine kinase consisting of internal tandem duplications (ITD) have been detected in blasts from 20–30% of patients with acute myeloid leukemia (AML) and are associated with a poor prognosis. FLT3/ITD results in constitutive auto-phosphorylation of the receptor and f...

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Hlavní autoři: Ahmad, Rehan, Liu, Suiyang, Weisberg, Ellen, Nelson, Erik, Galinsky, Ilene, Meyer, Colin, Kufe, Donald, Kharbanda, Surender, Stone, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905481/
https://ncbi.nlm.nih.gov/pubmed/20571062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-10-0154
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