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DC-HIL/Gpnmb promotes growth of melanoma in mice by inhibiting the activation of tumor-reactive T cells

DC-HIL/Gpnmb expressed on antigen-presenting cells (APC) attenuates T cell activation by binding to syndecan-4 (SD-4) on activated T cells. Since DC-HIL/Gpnmb is expressed abundantly by mouse and human melanoma lines, we posited that melanoma-associated DC-HIL/Gpnmb exerts similar inhibitory functio...

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Detalhes bibliográficos
Main Authors: Tomihari, Mizuki, Chung, Jin-Sung, Akiyoshi, Hideo, Cruz, Ponciano D., Ariizumi, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905472/
https://ncbi.nlm.nih.gov/pubmed/20570888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2538
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