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Probing the Mechanism of pH-Induced Large-Scale Conformational Changes in Dengue Virus Envelope Protein Using Atomistic Simulations

One of the key steps in the infection of the cell by dengue virus is a pH-induced conformational change of the viral envelope proteins. These envelope proteins undergo a rearrangement from a dimer to a trimer, with large conformational changes in the monomeric unit. In this article, metadynamics sim...

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Detalhes bibliográficos
Main Authors: Prakash, Meher K., Barducci, Alessandro, Parrinello, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905125/
https://ncbi.nlm.nih.gov/pubmed/20643078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.024
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