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How Pancreatic β-Cells Discriminate Long and Short Timescale cAMP Signals

The translocation of catalytic protein kinase A (cPKA) in response to cyclic-adenosine mono-phosphate (cAMP) depends on the pattern of stimulus applied to the cell. Experiments with IBMX have shown that 1), sustained cAMP elevation is more effective than oscillations of cAMP at getting cPKA into the...

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Detalles Bibliográficos
Main Authors: Peercy, Bradford E., Sherman, Arthur S.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905120/
https://ncbi.nlm.nih.gov/pubmed/20643057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.043
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