Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detri...

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Hlavní autoři: Khurana, Vikram, Elson-Schwab, Ilan, Fulga, Tudor A., Sharp, Katherine A., Loewen, Carin A., Mulkearns, Erin, Tyynelä, Jaana, Scherzer, Clemens R., Feany, Mel B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904797/
https://ncbi.nlm.nih.gov/pubmed/20664788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001026
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