Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detri...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Khurana, Vikram, Elson-Schwab, Ilan, Fulga, Tudor A., Sharp, Katherine A., Loewen, Carin A., Mulkearns, Erin, Tyynelä, Jaana, Scherzer, Clemens R., Feany, Mel B.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2010
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904797/
https://ncbi.nlm.nih.gov/pubmed/20664788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001026
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