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Neutrophils exposed to A. phagocytophilum under shear stress fail to fully activate, polarize, and transmigrate across inflamed endothelium

Anaplasma phagocytophilum is an obligate intracellular bacterium that has evolved mechanisms to hijack polymorphonuclear neutrophil (PMN) receptors and signaling pathways to bind, infect, and multiply within the host cell. E-selectin is upregulated during inflammation and is a requisite endothelial...

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Bibliografiske detaljer
Main Authors: Schaff, U. Y., Trott, K. A., Chase, S., Tam, K., Johns, J. L., Carlyon, J. A., Genetos, D. C., Walker, N. J., Simon, S. I., Borjesson, D. L.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904253/
https://ncbi.nlm.nih.gov/pubmed/20392928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00165.2009
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