Neutrophils exposed to A. phagocytophilum under shear stress fail to fully activate, polarize, and transmigrate across inflamed endothelium

Anaplasma phagocytophilum is an obligate intracellular bacterium that has evolved mechanisms to hijack polymorphonuclear neutrophil (PMN) receptors and signaling pathways to bind, infect, and multiply within the host cell. E-selectin is upregulated during inflammation and is a requisite endothelial...

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Detalhes bibliográficos
Main Authors: Schaff, U. Y., Trott, K. A., Chase, S., Tam, K., Johns, J. L., Carlyon, J. A., Genetos, D. C., Walker, N. J., Simon, S. I., Borjesson, D. L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Receptors and Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904253/
https://ncbi.nlm.nih.gov/pubmed/20392928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00165.2009
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