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Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding

In peripheral tissues, the link between obesity and insulin resistance involves low-grade inflammation induced by macrophage activation and proinflammatory cytokine signaling. Since proinflammatory cytokines are also induced in the hypothalamus of animals placed on a high-fat (HF) diet and can inhib...

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Autors principals: Oh-I, Shinsuke, Thaler, Joshua P., Ogimoto, Kayoko, Wisse, Brent E., Morton, Gregory J., Schwartz, Michael W.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904047/
https://ncbi.nlm.nih.gov/pubmed/20371733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00026.2010
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