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The Roles of ATF3, an Adaptive-Response Gene, in High-Fat-Diet-Induced Diabetes and Pancreatic β-Cell Dysfunction

Most people with type 2 diabetes (T2D) have reduced β-cell mass, and apoptosis is a key factor for this reduction. Previously, we showed that ATF3, an adaptive-response gene, is induced by various stress signals relevant to T2D, such as high glucose and high fatty acid. Because ATF3 is proapoptotic...

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Bibliografiske detaljer
Main Authors: Zmuda, Erik J., Qi, Ling, Zhu, Michael X., Mirmira, Raghavendra G., Montminy, Marc R., Hai, Tsonwin
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903910/
https://ncbi.nlm.nih.gov/pubmed/20519332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0463
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