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Design, Synthesis, and Investigation of Protein Kinase C Inhibitors: Total Syntheses of (+)-Calphostin D, (+)- Phleichrome, Cercosporin and New Photoactive Perylenequinones

The total syntheses of the PKC inhibitors (+)-calphostin D, (+)-phleichrome, cercosporin, and 10 novel perylenequinones are detailed. The highly convergent and flexible strategy developed employed an enantioselective oxidative biaryl coupling and a double cuprate epoxide opening, allowing the select...

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Autors principals: Morgan, Barbara J., Dey, Sangeeta, Johnson, Steven W., Kozlowski, Marisa C.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903893/
https://ncbi.nlm.nih.gov/pubmed/19489582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja902324j
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