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Rapid, nongenomic estrogen actions protect pancreatic islet survival

The gonadal steroid, 17β-estradiol (E(2)), acts as a protective hormone preventing β-cell apoptosis in vivo in mice of both sexes and in cultured mouse and human islets. E(2) signals via the classical estrogen receptor (ER)α and ERβ, an extranuclear form of ERα and the G protein-coupled estrogen rec...

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Bibliographic Details
Main Authors: Liu, Suhuan, Mauvais-Jarvis, Franck
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903892/
https://ncbi.nlm.nih.gov/pubmed/20634925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.1.3.9781
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