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Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice

The heart of leptin-deficient ob/ob mice is characterized by pathologic left ventricular hypertrophy along with elevated triglyceride (TG) content, increased stearoyl-CoA desaturase (SCD) activity, and increased myocyte apoptosis. In the present study, using an ob/ob;SCD1(−/−) mouse model, we tested...

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Main Authors: Dobrzyn, Pawel, Dobrzyn, Agnieszka, Miyazaki, Makoto, Ntambi, James M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2010
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903830/
https://ncbi.nlm.nih.gov/pubmed/20363835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M003780
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