Rearrangements of the RAF Kinase Pathway in Prostate Cancer, Gastric Cancer and Melanoma

While recurrent gene fusions involving ETS family transcription factors are common in prostate cancer, their products are considered “undruggable” by conventional approaches. Recently, rare “targetable” gene fusions (involving the ALK kinase), have been identified in 1–5% of lung cancers1, suggestin...

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Huvudupphovsmän: Palanisamy, Nallasivam, Ateeq, Bushra, Kalyana-Sundaram, Shanker, Pflueger, Dorothee, Ramnarayanan, Kalpana, Shankar, Sunita, Han, Bo, Cao, Qi, Cao, Xuhong, Suleman, Khalid, Kumar-Sinha, Chandan, Dhanasekaran, Saravana M., Chen, Ying-bei, Esgueva, Raquel, Banerjee, Samprit, LaFargue, Christopher J., Siddiqui, Javed, Demichelis, Francesca, Moeller, Peter, Bismar, Tarek A., Kuefer, Rainer, Fullen, Douglas R., Johnson, Timothy M., Greenson, Joel K., Giordano, Thomas J., Tan, Patrick, Tomlins, Scott A., Varambally, Sooryanarayana, Rubin, Mark A., Maher, Christopher A., Chinnaiyan, Arul M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903732/
https://ncbi.nlm.nih.gov/pubmed/20526349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2166
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