Synthesis and biodistribution of [(11)C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB(2))

Recently, A-836339 [2,2,3,3-tetramethylcyclopropanecarboxylic acid [3-(2-methoxyethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]amide] (1) was reported to be a selective CB(2) agonist with high binding affinity. Here we describe the radiosynthesis of [(11)C]A-836339 ([(11)C]1) via its desmethyl precurso...

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Autors principals: Horti, Andrew G., Gao, Yongjun, Ravert, Hayden T., Finley, Paige, Valentine, Heather, Wong, Dean F., Endres, Christopher J., Savonenko, Alena V., Dannals, Robert F.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903661/
https://ncbi.nlm.nih.gov/pubmed/20554448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.05.058
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