Hemoglobin-induced oxidative stress contributes to matrix metalloproteinase activation and blood–brain barrier dysfunction in vivo

Hemoglobin (Hb) released from extravasated erythrocytes is implicated in brain edema after intracerebral hemorrhage (ICH). Hemoglobin is a major component of blood and a potent mediator of oxidative stress after ICH. Oxidative stress and matrix metalloproteinases (MMPs) are associated with blood–bra...

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Autors principals: Katsu, Masataka, Niizuma, Kuniyasu, Yoshioka, Hideyuki, Okami, Nobuya, Sakata, Hiroyuki, Chan, Pak H
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903654/
https://ncbi.nlm.nih.gov/pubmed/20354546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.45
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