Hemoglobin-induced oxidative stress contributes to matrix metalloproteinase activation and blood–brain barrier dysfunction in vivo

Hemoglobin (Hb) released from extravasated erythrocytes is implicated in brain edema after intracerebral hemorrhage (ICH). Hemoglobin is a major component of blood and a potent mediator of oxidative stress after ICH. Oxidative stress and matrix metalloproteinases (MMPs) are associated with blood–bra...

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Detalhes bibliográficos
Main Authors: Katsu, Masataka, Niizuma, Kuniyasu, Yoshioka, Hideyuki, Okami, Nobuya, Sakata, Hiroyuki, Chan, Pak H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903654/
https://ncbi.nlm.nih.gov/pubmed/20354546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.45
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