MECHANISMS OF ACQUIRED RESISTANCE TO CETUXIMAB: ROLE OF HER (ErbB) FAMILY MEMBERS

The epidermal growth factor receptor (EGFR) is a central regulator of proliferation and progression in human cancers. Five EGFR inhibitors, two monoclonal antibodies and three TKIs, have recently gained FDA approval in oncology (cetuximab, panitumumab, erlotinib, gefitinib and lapatinib). These stra...

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Bibliographic Details
Main Authors: Wheeler, Deric L., Huang, Shyhmin, Kruser, Tim J., Nechrebecki, Meghan M., Armstrong, Eric A., Benavente, Sergio, Gondi, Vinai, Hsu, Kun-Tai, Harari, Paul M.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903615/
https://ncbi.nlm.nih.gov/pubmed/18297114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.19
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