Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice

BACKGROUND: Inhibin is a tumor-suppressor and activin antagonist. Inhibin-deficient mice develop gonadal tumors and a cachexia wasting syndrome due to enhanced activin signaling. Because activins signal through SMAD2 and SMAD3 in vitro and loss of SMAD3 attenuates ovarian tumor development in inhibi...

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Autori principali: Rajanahally, Saneal, Agno, Julio E, Nalam, Roopa L, Weinstein, Michael B, Loveland, Kate L, Matzuk, Martin M, Li, Qinglei
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903601/
https://ncbi.nlm.nih.gov/pubmed/20565978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-7827-8-69
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