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Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice
BACKGROUND: Inhibin is a tumor-suppressor and activin antagonist. Inhibin-deficient mice develop gonadal tumors and a cachexia wasting syndrome due to enhanced activin signaling. Because activins signal through SMAD2 and SMAD3 in vitro and loss of SMAD3 attenuates ovarian tumor development in inhibi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903601/ https://ncbi.nlm.nih.gov/pubmed/20565978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-7827-8-69 |
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