Using the realized relationship matrix to disentangle confounding factors for the estimation of genetic variance components of complex traits

BACKGROUND: In the analysis of complex traits, genetic effects can be confounded with non-genetic effects, especially when using full-sib families. Dominance and epistatic effects are typically confounded with additive genetic and non-genetic effects. This confounding may cause the estimated genetic...

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Main Authors: Lee, Sang Hong, Goddard, Michael E, Visscher, Peter M, van der Werf, Julius HJ
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903499/
https://ncbi.nlm.nih.gov/pubmed/20546624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1297-9686-42-22
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