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Glycosylphosphatidylinositol Anchor Analogues Sequester Cholesterol and Reduce Prion Formation
A hallmark of prion diseases is the conversion of the host-encoded prion protein (PrP(C) where C is cellular) into an alternatively folded, disease-related isoform (PrP(Sc), where Sc is scrapie), the accumulation of which is associated with synapse degeneration and ultimately neuronal death. The for...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2903401/ https://ncbi.nlm.nih.gov/pubmed/20427265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.108548 |
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