Akt-phosphorylated Mitogen-activated Kinase-activating Death Domain Protein (MADD) Inhibits TRAIL-induced Apoptosis by Blocking Fas-associated Death Domain (FADD) Association with Death Receptor 4

MADD plays an essential role in cancer cell survival. Abrogation of endogenous MADD expression results in significant spontaneous apoptosis and enhanced susceptibility to tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. However, the regulation of MADD function is...

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Detalhes bibliográficos
Main Authors: Li, Peifeng, Jayarama, Shankar, Ganesh, Lakshmy, Mordi, David, Carr, Ryan, Kanteti, Prasad, Hay, Nissim, Prabhakar, Bellur S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903385/
https://ncbi.nlm.nih.gov/pubmed/20484047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105692
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