Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

Epidemiological studies suggest that statins (hydroxymethylglutaryl-CoA reductase inhibitors) could reduce the risk of Alzheimer disease. Although one possible explanation is through an effect on β-amyloid (Aβ) metabolism, its effect remains to be elucidated. Here, we explored the molecular mechanis...

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Detalhes bibliográficos
Main Authors: Shinohara, Mitsuru, Sato, Naoyuki, Kurinami, Hitomi, Takeuchi, Daisuke, Takeda, Shuko, Shimamura, Munehisa, Yamashita, Toshihide, Uchiyama, Yasuo, Rakugi, Hiromi, Morishita, Ryuichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903370/
https://ncbi.nlm.nih.gov/pubmed/20472556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102277
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