The Fe/S Cluster Assembly Protein Isd11 Is Essential for tRNA Thiolation in Trypanosoma brucei

Fe/S clusters are part of the active site of many enzymes and are essential for cell viability. In eukaryotes the cysteine desulfurase Nfs (IscS) donates the sulfur during Fe/S cluster assembly and was thought sufficient for this reaction. Moreover, Nfs is indispensable for tRNA thiolation, a modifi...

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Autors principals: Paris, Zdeněk, Changmai, Piya, Rubio, Mary Anne T., Zíková, Alena, Stuart, Kenneth D., Alfonzo, Juan D., Lukeš, Julius
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903368/
https://ncbi.nlm.nih.gov/pubmed/20442400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083774
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