Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK

The thioesterase FlK from the fluoroacetate-producing Streptomyces cattleya catalyzes the hydrolysis of fluoroacetyl-coenzyme A. This provides an effective self-defense mechanism, preventing any fluoroacetyl-coenzyme A formed from being further metabolized to 4-hydroxy-trans-aconitate, a lethal inhi...

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Main Authors: Dias, Marcio V. B., Huang, Fanglu, Chirgadze, Dimitri Y., Tosin, Manuela, Spiteller, Dieter, Dry, Emily F. V., Leadlay, Peter F., Spencer, Jonathan B., Blundell, Tom L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903362/
https://ncbi.nlm.nih.gov/pubmed/20430898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.107177
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