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Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity(,)

We have initiated a broad-based program aimed at understanding the molecular basis of fluorine specificity in enzymatic systems, and in this context, we report crystallographic and biochemical studies on a fluoroacetyl-coenzyme A (CoA) specific thioesterase (FlK) from Streptomyces cattleya. Our data...

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Detalhes bibliográficos
Main Authors: Weeks, Amy M., Coyle, Scott M., Jinek, Martin, Doudna, Jennifer A., Chang, Michelle C. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461317/
https://ncbi.nlm.nih.gov/pubmed/20836570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101102u
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