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The Virion Host Shutoff Endonuclease (UL41) of Herpes Simplex Virus Interacts with the Cellular Cap-Binding Complex eIF4F

The herpes simplex virus Vhs endonuclease degrades host and viral mRNAs. Isolated Vhs cuts any RNA at many sites. Yet, within cells, it targets mRNAs and cuts at preferred sites, including regions of translation initiation. Previous studies have shown that Vhs binds the translation factors eIF4A and...

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Bibliografske podrobnosti
Main Authors: Page, Heidi G., Read, G. Sullivan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903273/
https://ncbi.nlm.nih.gov/pubmed/20427534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00166-10
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