Suppression of a Morphogenic Mutant in Rous Sarcoma Virus Capsid Protein by a Second-Site Mutation: a Cryoelectron Tomography Study

Retrovirus assembly is driven by polymerization of the Gag polyprotein as nascent virions bud from host cells. Gag is then processed proteolytically, releasing the capsid protein (CA) to assemble de novo inside maturing virions. CA has N-terminal and C-terminal domains (NTDs and CTDs, respectively)...

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Main Authors: Butan, Carmen, Lokhandwala, Parvez M., Purdy, John G., Cardone, Giovanni, Craven, Rebecca C., Steven, Alasdair C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Structure and Assembly
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903260/
https://ncbi.nlm.nih.gov/pubmed/20427531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00207-10
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