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Lethal mutations in the major homology region and their suppressors act by modulating the dimerization of the Rous sarcoma virus capsid protein C-terminal domain

An infective retrovirus requires a mature capsid shell around the viral replication complex. This shell is formed by about 1500 capsid protein monomers, organized into hexamer and pentamer rings that are linked to each other by the dimerization of the C-terminal domain (CTD). The major homology regi...

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Detalhes bibliográficos
Main Authors: Dalessio, Paula M., Craven, Rebecca C., Lokhandwala, Parvez M., Ropson, Ira J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657841/
https://ncbi.nlm.nih.gov/pubmed/23011855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24188
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