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Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors

BACKGROUND: Germline mutations in DNA mismatch repair (MMR) genes cause Lynch syndrome colon cancers. Less understood is the risk of colon cancer associated with common polymorphisms in MMR genes and the potential interacting role of lifestyle factors known to damage DNA. METHODS: A study was conduc...

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Détails bibliographiques
Auteurs principaux: Campbell, P T, Curtin, K, Ulrich, C M, Samowitz, W S, Bigler, J, Velicer, C M, Caan, B, Potter, J D, Slattery, M L
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903215/
https://ncbi.nlm.nih.gov/pubmed/18523027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2007.144220
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