A Single Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic Alpha-Exosite Binding Region

Ingestion or inhalation of botulinum neurotoxin (BoNT) results in botulism, a severe and frequently fatal disease. Current treatments rely on antitoxins, which while effective cannot reverse symptoms once BoNT has entered the neuron. For treatments that can reverse intoxication, interest has focused...

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Main Authors: Dong, Jianbo, Thompson, Aaron A., Fan, Yongfeng, Lou, Jianlong, Conrad, Fraser, Ho, Mengfei, Pires-Alves, Melissa, Wilson, Brenda A., Stevens, Raymond C., Marks, James D.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903050/
https://ncbi.nlm.nih.gov/pubmed/20138889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.070
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