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Crystal Structure of RAIDD Death Domain Implicates Potential Mechanism of PIDDosome Assembly
Caspase-2 is implicated in stress-induced apoptosis that acts as an upstream initiator of mitochondrial permeabilization. Recent studies have shown that caspase-2 activation requires a molecular complex known as the PIDDosome comprising the p53 inducible protein PIDD, the adapter protein RAIDD and c...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902980/ https://ncbi.nlm.nih.gov/pubmed/16434054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2005.12.082 |
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